Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice
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چکیده
منابع مشابه
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice.
Sepsis induces an acute inflammatory response in the liver, which can lead to organ failure and death. Given the anti-inflammatory effects of exercise, we hypothesized that habitual physical activity could protect against acute sepsis-induced liver inflammation via mechanisms, including heat shock protein (HSP) 70/72. Male C57BL/6J mice (n = 80, ∼8 wk of age) engaged in physical activity via vo...
متن کاملMEMRI Study of Mice Cerebellar Activation after Voluntary Wheel Running
INTRODUCTION: There is increasing interest in studying functional and cellular effects of environmental stimuli for better intervention in neurological rehabilitation [1, 2]. Recent studies have been using BOLD-fMRI to detect the neural activity in living animals [3] and human [4]. However it is technically difficult to apply BOLD-fMRI to nonrestrained animals due to its extreme susceptibility ...
متن کاملNeurobiology of Mice Selected for High Voluntary Wheel-running Activity.
Selective breeding of house mice has been used to study the evolution of locomotor behavior. Our model consists of 4 replicate lines selectively bred for high voluntary wheel running (High-Runner) and 4 bred randomly (Control). The major changes in High-Runner lines appear to have taken place in the brain rather than in capacities for exercise. Their neurobiological profile resembles features o...
متن کاملNeurobiology of Mice Selected for High Voluntary Wheel-running Activity1
SYNOPSIS. Selective breeding of house mice has been used to study the evolution of locomotor behavior. Our model consists of 4 replicate lines selectively bred for high voluntary wheel running (High-Runner) and 4 bred randomly (Control). The major changes in High-Runner lines appear to have taken place in the brain rather than in capacities for exercise. Their neurobiological profile resembles ...
متن کاملAgenesis of the corpus callosum and voluntary wheel running in mice
Humans born without a corpus callosum (CC) are often comparatively slow and clumsy on tasks requiring bilateral motor coordination. In this study, we attempted to identify correlates of CC agenesis in mice by examining an ecologically valid motor behavior: running-wheel performance. Mice with varying degrees of congenital CC deficits were tested on a running wheel apparatus for 7 consecutive da...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2019
ISSN: 1756-6606
DOI: 10.1186/s13041-019-0506-8